Mechanism of Action

RADIESSE® is an injectable implant composed of smooth calcium hydroxylapatite (CaHA) microspheres (diameter of 25 µm to 45 µm) suspended in a sodium carboxymethylcellulose gel carrier. RADIESSE is approximately 30% CaHA and 70% gel carrier by volume.

RADIESSE is injected under the skin in a minimally invasive procedure. Injection of the product provides an immediate and visible correction to the wrinkle. There is no skin sensitivity testing or reconstitution required.

Over time, the gel is absorbed, and fibroblasts appear. The process of neocollagenesis begins, stimulating the gradual growth of the patient’s own collagen.1 The collagen that forms results in extended correction and increased patient satisfaction. Clinical results have been shown to last a year or more in many patients.2,3


RADIESSE® Histology Slides

Histology slides demonstrate deposition of new collagen around CaHA microspheres over an extended period of time. Collagen fibers stain red, while other tissue elements appear more yellow.1


The cosmetic results are immediate, natural and subtle. The correction is long-lasting, but not permanent. The CaHA microspheres naturally degrade to calcium and phosphate ions, which are metabolized by the body’s normal processes.2,3

It is important to remember not to overcorrect (overfill) a contour deficiency with RADIESSE because the depression should gradually improve within several weeks as the treatment effect of RADIESSE occurs.

How It Works